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1996 1
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The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.
Theos AC, Watt B, Harper DC, Janczura KJ, Theos SC, Herman KE, Marks MS. Theos AC, et al. Pigment Cell Melanoma Res. 2013 Jul;26(4):470-86. doi: 10.1111/pcmr.12084. Epub 2013 Apr 2. Pigment Cell Melanoma Res. 2013. PMID: 23452376 Free PMC article.
Using domain swapping, the unique PMEL localization is ascribed to its polycystic kidney disease (PKD) domain, whereas the homologous PKD domain of GPNMB lacks apparent sorting function. ...These results reveal the molecular basis for the distinct trafficking and mo …
Using domain swapping, the unique PMEL localization is ascribed to its polycystic kidney disease (PKD) domain, whereas the hom …
A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma.
Venyo AK. Venyo AK. Int J Surg Oncol. 2016;2016:6347136. doi: 10.1155/2016/6347136. Epub 2016 Feb 17. Int J Surg Oncol. 2016. PMID: 26989509 Free PMC article. Review.
One case of retroperitoneal angiomyolipoma was reported in a patient 15 years after undergoing radical nephrectomy for angiomyolipoma of kidney and two cases of distant metastases of angiomyolipoma have been reported following radical resection of the tumour. ...
One case of retroperitoneal angiomyolipoma was reported in a patient 15 years after undergoing radical nephrectomy for angiomyolipoma of …
Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis.
Knaust J, Weikard R, Albrecht E, Brunner RM, Günther J, Kühn C. Knaust J, et al. Genes (Basel). 2020 Jul 13;11(7):788. doi: 10.3390/genes11070788. Genes (Basel). 2020. PMID: 32668786 Free PMC article.
Reports about PMEL gene expression in non-pigmented tissues raised the hypothesis that there may be unknown functions of the PMEL protein beyond eumelanin deposition to PMEL fibrils. In our study, we analysed the PMEL protein expression in pigmented sk …
Reports about PMEL gene expression in non-pigmented tissues raised the hypothesis that there may be unknown functions of the PMEL …
Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis.
Han F, Dellacecca ER, Barse LW, Cosgrove C, Henning SW, Ankney CM, Jaishankar D, Yemelyanov A, Krymskaya VP, Dilling DF, Le Poole IC. Han F, et al. Am J Respir Cell Mol Biol. 2020 Jun;62(6):793-804. doi: 10.1165/rcmb.2019-0117OC. Am J Respir Cell Mol Biol. 2020. PMID: 32078336 Free PMC article.
T cells were isolated from major histocompatibility complex-matched TCR transgenic pmel-1 mice to measure cytotoxicity in vitro, and 80% cytotoxicity was observed within 48 hours. Antigen-specific cytotoxicity was likewise observed using pmel-1 TCR-transduced mouse …
T cells were isolated from major histocompatibility complex-matched TCR transgenic pmel-1 mice to measure cytotoxicity in vitro, and …
[Angiomyolipoma with Epithelial Cysts (AMLEC) of the Kidney].
Takei K, Shimizu S, Otsuki Y. Takei K, et al. Hinyokika Kiyo. 2016 Jul;62(7):355-60. doi: 10.14989/ActaUrolJap_62_7_355. Hinyokika Kiyo. 2016. PMID: 27569353 Free article. Review. Japanese.
A 49-year-old man was demonstrated to have two tumors in the right kidney by computed tomographic scan during an examination for cholelithiasis. ...
A 49-year-old man was demonstrated to have two tumors in the right kidney by computed tomographic scan during an examination for chol …
Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.
Johansson P, Kaspersson K, Gurrell IK, Bäck E, Eketjäll S, Scott CW, Cebers G, Thorne P, McKenzie MJ, Beaton H, Davey P, Kolmodin K, Holenz J, Duggan ME, Budd Haeberlein S, Bürli RW. Johansson P, et al. J Med Chem. 2018 Apr 26;61(8):3491-3502. doi: 10.1021/acs.jmedchem.7b01716. Epub 2018 Apr 10. J Med Chem. 2018. PMID: 29617572
Compared to a nonselective BACE1/2 inhibitor, 28 showed significantly less inhibition of PMEL processing in human melanocytes, indicating good functional selectivity of this inhibitor class....
Compared to a nonselective BACE1/2 inhibitor, 28 showed significantly less inhibition of PMEL processing in human melanocytes, indica …
Melanotic Xp11 translocation renal cancer: a report of a distinctive case and a review of the literature.
Jing H, Wei H, Yuan H, Li Y, Li N, Mu D. Jing H, et al. Diagn Pathol. 2018 Aug 13;13(1):51. doi: 10.1186/s13000-018-0731-y. Diagn Pathol. 2018. PMID: 30103811 Free PMC article. Review.
Abdominal ultrasonography and computed tomography (CT) scans revealed a 4.5 cm 4.0 cm mass in the left kidney. Grossly, the well-demarcated mass was black with moderately firm consistency. ...
Abdominal ultrasonography and computed tomography (CT) scans revealed a 4.5 cm 4.0 cm mass in the left kidney. Grossly, the well-dema …
PEComa of the urinary bladder.
Shringarpure SS, Thachil JV, Maya M. Shringarpure SS, et al. Saudi J Kidney Dis Transpl. 2012 Sep;23(5):1032-4. doi: 10.4103/1319-2442.100943. Saudi J Kidney Dis Transpl. 2012. PMID: 22982918
Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils.
Leonhardt RM, Vigneron N, Hee JS, Graham M, Cresswell P. Leonhardt RM, et al. Mol Biol Cell. 2013 Apr;24(7):964-81. doi: 10.1091/mbc.E12-10-0742. Epub 2013 Feb 6. Mol Biol Cell. 2013. PMID: 23389629 Free PMC article.
PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome development by forming a fibrillar amyloid matrix in the organelle for melanin deposition. Although ultimately not a component of mature fibrils, the …
PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome developmen …
40 results